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Presentation

Chemistry of biological processes
CNRS UMR 8229
Collège de France, Paris

Diector : Professor Marc Fontecave

The research unit is connected to the Chemistry Department of the University Pierre et Marie Curie.

The research projects of the laboratory join in the field of molecular chemistry, inorganic (coordination and organometallic chemistry) and biological chemistry (protein chemistry). They involve the implementation of skills in chemical, organic and inorganic, synthesis, in chemical analysis (electrochemistry in particular) and in catalysis, as well as in enzymology and in structural biology. An important activity of crystallization of proteins and determination of their three-dimensional structures leans on a platform of high technicality (glove boxes, robots, microscopes). The studied systems are complex enzymes which display interesting and original structural organizations and chemical reactivities (enzymatic mechanisms). They have potential
applications in particular in the field of the health, energy and biocatalysis. Few examples of projects are those concerning natural and artificial hydrogenases (project 1), enzymes (flavoproteins and metalloenzymes) involved in the biosynthesis of ubiquinone (project 2) or enzymes of maturation of nucleic acids (project 3). These systems, more particularly their active sites, constitute unique sources of inspiration for the synthetic chemists. This biomimetic or bioinspired chemistry approach allows
developping original catalysts, in particular for applications in the field of the new energy technologies. The objective is to work out electrodes and photoelectrodes for technological devices (electrolyzers coupled to solar panels and photoelectrochemical cells) for storage of renewable energies (solar) through the (photo) decomposition of water into hydrogen and oxygen or through the reduction of the CO2 in energy-dense cn molecules (project 1).

Research project 1

Artificial Photosynthesis: transformation of water and cn
dioxide into fuels

Group leaders: Marc Fontecave, Caroline Mellot-Draznieks

Permanent staff involved in the project: Caroline Mellot-Draznieks (DR2 CNRS), Yun Xu-Li (IR HC CNRS), Philippe Simon (IR2 CNRS), Maria Gomez-Mingot (IR CDF), Ludovic Pecqueur (IR CDF) and Marc Fontecave (Pr CDF)

Engineers under project contract: Tran Ngoc Huan, Tanya Todorova Students (PhD and post-docs): Grégoire Paille, Dilan Karapinar, Cecilia Papini, David Wakerley, Sarah Lamaison, Hemlata Agarwala, Ahmed Mouchfik, Laura Ellezam, Mathis
Duguet, Youven Benséghir, Ellie Vichou, Adèle Peugeot, Yann Méheust

Project Overview  [2747.0Ko]

Research project 2

Multi-protein complex for ubiquinone biosynthesis: biochemical
and structural studies

Permanent staff involved in the project: Murielle Lombard (CR1 CNRS), Ludovic Pecqueur (IR CDF), Bruno Faivre (IE, CDF), Marc Fontecave (Pr CDF)

Students (PhD and post-docs): Cameron Fyfe, Chau-Duy-Tam Vo, Yifan deng

Project overview  [841.0Ko]

Research project 3

tRNA maturation enzymes

Group leaders: Béatrice Golinelli-Pimpaneau, Djemel Hamdane

Permanent staff involved in the project:  Béatrice Golinelli-Pimpaneau (DR2, CNRS), Djemel Hamdane (CR1, CNRS), Murielle Lombard (CR1, CNRS), Bruno Faivre (IE, CDF), Marc Fontecave (Pr CDF)

Students (PhD and post-docs): Dona Sleiman, Nisha He

Project overview  [2224.0Ko]

Team Members

Team Members